TORONTO — Ontario prosecutors want a Toronto man who tried to join Islamic State militants in Syria to be sentenced to six years behind bars.Pamir Hakimzadah, 29, pleaded guilty in early February to one count of leaving Canada to participate in a terrorist activity.At a sentencing hearing taking place today, Crown lawyer Christopher Walsh says the court has no insight into how Hakimzadah became radicalized and is dubious of a plan from the defence for their client’s de-radicalization.Court heard Hakimzadah left Toronto in October 2014 and flew to Istanbul with the goal of finding a way into Syria to join the Islamic State of Iraq and the Levant.He was turned in to authorities by a taxi driver in Turkey who suspected Hakimzadah wanted to join the terrorist group, and was sent back to Canada where he was later turned in by a family member.Hakimzadah admitted he viewed Islamic State militant propaganda videos online and became sympathetic to their viewpoint.The Canadian Press
Facebook Advertisement Advertisement LEAVE A REPLY Cancel replyLog in to leave a comment Advertisement Whistler, B.C. (November 14, 2017) – In a few weeks, the Whistler Film Festival (WFF) will shine the spotlight on some of the industry’s top talent in it’s Signature Series, which features four events that recognize distinguished artists of our time and honours them with an award and or intimate on-stage interview complemented by a feature presentation of their most recent film premiering at the fest.For its 17th edition, WFF proudly celebrates American actress and producer Kyra Sedgwick, who is attending the festival with her directorial debut and Canadian premiere of STORY OF A GIRL and as the Artist Spotlight and Luminary Award honouree. WFF is also thrilled to honour acclaimed American actor Bill Pullman, who is attending with the Canadian premiere of THE BALLAD OF LEFTY BROWN and as the Artist Tribute and Career Achievement Award honouree. Sedgwick and Pullman join this year’s Variety 10 Screenwriters to Watch as well as actors Amanda Crew, Kevin Zegers, Rossif Sutherland and Shiva Negar who will be featured in a new Canada 150 Spotlight on Talent conversation to mark the centennial hosted by Canadian television and radio personality, George Stroumboulopoulos.“WFF’s 2017 honourees represent notable talent at different stages of their careers. Some have created the most memorable stories and characters in recent decades and others have careers about to burst,” says Whistler Film Festival’s Director of Industry Programming, Angie Nolan. “It is such an honour to celebrate this diverse group of inspiring artists at all phases of their creative journey.” Twitter Award winning actor Kyra Sedgwick has conquered stage, screen and television. Sedgwick is WFF’s Artist Spotlight honouree and will be receiving a Luminary Award, which recognizes a sublime artist whose body of work continues to inspire while shining a light on meaningful storytelling. Sedgwick has received multiple Golden Globe nominations (2007 win for THE CLOSER), Emmy nominations (2010 win for THE CLOSER), 7 SAG nominations as well as two Independent Spirit Award nominations, a Theater Award, Los Angeles Drama Desk Critics Circle Award and a Dramalogue Award. She is currently starring in and producing ABC’s limited series TEN DAYS IN THE VALLEY. She recently appeared in THE EDGE OF SEVENTEEN, written and directed by Kelly Fremon Craig, in which she co-stars opposite Woody Harrelson and Hailee Steinfeld, produced by James L. Brooks. Sedgwick is attending WFF with the Canadian premiere and her directorial debut, STORY OF A GIRL. The feature, which stars Ryann Shane alongside Sedgwick’s husband and daughter Kevin and Sosie Bacon, was originally produced for Lifetime and is based on a novel by Sara Zarr. With this film, Sedgwick tackles the very topical subject of online shaming and bullying with tact and sensitivity. A tale of personal courage and triumph, STORY OF A GIRL is a coming of age story about a young woman who finds the inner strength to overcome her past in order to become the author of her own future. Sedgwick displays a delicate sensitivity directing a young cast that has to deal with sensitive material at a time when stories like these are more important than ever. The event will be hosted by Canadian television and radio personality, George Stroumboulopoulos on December 1 at 1:30pm.Beloved American actor, Bill Pullman of stage, screen and television is WFF’s Tribute guest and the recipient of its’ 2017 Career Achievement Award. This award recognizes a formidable talent in film and television, whose longevity in storytelling and artistic achievement has culminated in a most prolific and inspiring career. Bill Pullman had his film debut in the 1986 film RUTHLESS PEOPLE and has since gone on to star in a multitude of films and television series where he created some of the most memorable characters in recent times. He is most known for his role as President Thomas J. Whitmore in INDEPENDENCE DAY as well as his role as Lone Starr in SPACEBALLS. Pullman can currently be seen on the hit USA television show, THE SINNER, which has been this summer’s highest rated show. Other notable film credits include: TROUBLE, WALKING OUT, INDEPENDENCE DAY: RESURGENCE, THE EQUALIZER, SURVEILLANCE, THE COVE, BOTTLE SHOCK, SCARY MOVIE 4, THE GRUDGE, WHILE YOU WERE SLEEPING, THE LAST SEDUCTION, MR. JONES, MALICE, SLEEPLESS IN SEATTLE, A LEAGUE OF THEIR OWN, SINGLES, NEWSIES and LOST HIGHWAY. Additional television credits include 1600 PENN, TORCHWOOD and REVELATIONS. Current film releases include Fox’s BATTLE OF THE SEXES, appearing alongside Emma Stone and Steve Carrell, as well as Electric Entertainment’s LBJ in which he appears opposite Woody Harrelson. He is attending the Whistler Film Festival with A24’s western movie and the Canadian premiere of THE BALLAD OF LEFTY BROWN. The event will be hosted by “Our City Tonight” Co-Host and CTV Film Critic Jim Gordon on December 1 at 3:00pm.The Whistler Film Festival is proud to host the Variety 10 Screenwriters to Watch for the sixth consecutive year as the final event in its Signature Series program. Hosted by Variety VP & Executive Editor Steven Gaydos, festival goers will get the chance to hear from some of the brightest and most promising writers of the year and get the latest news and insights behind their upcoming projects at an afternoon conversation on December 2 at 3:00pm, and will be formally honoured at WFF’s Awards Celebration on December 3 at 10:00am. The screenwriters and notable credits will be announced shortly.To celebrate Canada’s 150, WFF’s presents a new event, Canada 150 Spotlight on Talent featuring four Canadian actors to watch who are attending the fest with their latest films in conversation with George Stroumboulopoulos. The roster includes Rossif Sutherland (TRENCH 11), Kevin Zegers (SOMEONE ELSE’S WEDDING), Amanda Crew (JUGGERNAUT), and Shiva Negar (BECOMING BURLESQUE), all of which are WFF Alumni having attended previous fests except for Shiva Negar. The event will be hosted by George Stroumboulopoulos on December 2 at 1:30PM.From November 29 to December 3, the Whistler Film Festival will welcome film fans and filmmakers to experience its 17th edition featuring 87 fresh films, special guests, epic events, unique industry and talent programs, and time to play in North America’s premier mountain resort. WFF combines an international film competition with a focused industry Summit dedicated to the art and business of filmmaking in the digital age that is connected to a slate of 11 talent programs for over 70 Canadian artists to develop their projects and craft.The Festival’s online box office at whistlerfilmfestival.com/attend/ is now open for VIP Patron Passes, Industry Passes and Ticket Packages. Single film and event tickets go on sale on November 15 (until December 3). The Festival Box Office is open for phone sales (1-877-838-FILM) and on November 24 for walk-up sales.Air travel and ground transportation deals as well as best accommodation rates are now available on whistlerfilmfestival.com/attend/. WFF has 20 accommodation partners to choose from including host hotel, the Westin Whistler Resort and Spa and VIP hotel the Fairmont Chateau Whistler Resort.The Whistler Film Festival is funded by the Government of Canada through Telefilm Canada and Western Economic Diversification, and by the Province of British Columbia and the Resort Municipality of Whistler, is supported by the Whistler Blackcomb Foundation and the American Friends of Whistler, and is sponsored by Variety, Creative BC, The Harold Greenberg Fund, the Canadian Media Producers Association, Cineplex, SW Event Technology, Remax Sea to Sky Real Estate, Whistler Blackcomb, Tourism Whistler, and the Westin Resort & Spa Whistler. Login/Register With:
A Ukrainian search and recovery team yesterday found the remains of the MI-8 helicopter which plunged into the sea shortly after takeoff while en route to Lungi Airport on 7 November with seven people on board, the Mission said. Recovery efforts were continuing, and so far, the bodies of three of the victims have been found.Also on Thursday, the deputy commander of the UN peacekeeping force in Sierra Leone, Maj. Gen. Martin Luther Agwai, visited the Kenyan Battalion stationed in the western town of Masiaka, in Port Loko District.Gen. Agwai toured some of the rebuilding projects completed by the Kenyan Battalion and later presented to two local schools stationery donated by the contingent. In an address to teachers, pupils and parents, he commended the community for providing a helpful environment for the Kenyan peacekeepers.Last week, the Kenyan Battalion handed over a Seventh Day Adventist church built by its troops to the community at Masiaka.
Following a stop in war-torn Bunia, Democratic Republic of the Congo (DRC), yesterday, the Security Council mission to West Africa, led by Ambassador Jean-Marc de La Sablière of France, is now in the Burundian capital of Bujumbura, where they have meetings scheduled with Vice President Alphonse Marie Kadege and President Domitien Ndayizeye.Upon arrival in the capital yesterday, Ambassador de La Sablière made a statement in which he expressed his congratulations to the Burundian people and the various political parties and groups for the successful conclusion and signing of ceasefire agreements, according to a UN spokesman in New York.Ambassador de La Sablière also expressed the Council’s support for the peace process and invited armed movements, which have not yet done so, to join the process. Tomorrow, the Council delegation travels to Kigali, Rwanda, to meet with President Paul Kagame.The spokesman reported that during yesterday’s three-hour visit to Bunia, the delegation was briefed on the deployment of the Emergency Interim Multinational Force by its commanding officer, Gen. Jean Marie Thonier of France. A meeting with the members of the Ituri Pacification Commission (IPC) – which rival militia and tribal groups agreed to set up to manage the region until a new post-war national government takes over – was to reinforce the support of the international community to that democratically elected body. The last of the delegation’s meetings was with non-governmental organizations (NGOs) and the humanitarian community. They raised fears that Bunia could become a big camp for displaced people if the mandate of the Multinational Force is to exclusively secure that town and its surroundings. They encouraged the UN to put an end to impunity in Bunia as the only way to discourage further violence and human rights violations against the civilians.In other news, the United Nations High Commissioner for Refugees reported that more than 1,300 Central African Republic (CAR) refugees from the northwestern DRC returned home when the agency launched a recent repatriation programme. The plan was initiated to assist some 2,600 CAR refugees in a camp at Mole, near the small town of Zongo on the Oubangui river.Daily truck convoys bring the refuges from Mole to Zongo, where they board UNHCR-contracted boats for a 10-minute ferry ride to the CAR capital of Bangui. Yesterday, the agency transported 500 refugees to Bangui and, if the current pace continues, the repatriation may be completed over the weekend. UNHCR added that CAR refugees from the Republic of the Congo have also begun to return, with an initial group of 57 flown home from Brazzaville earlier in the week.
Anwarul Chowdhury, Under-Secretary-General and High Representative for Least Developed Countries, Landlocked Developing Countries and SIDS, told the General Assembly’s Economic and Financial Committee that “the widest possible range of stakeholders, including Member States, multilateral financial institutions, the private sector, non-governmental organizations (NGOs), and other civil society organizations should participate” in the conference to be held next August in Mauritius.The meeting is a 10-year review of the implementation of the Barbados Programme of Action for the Sustainable Development of Small Island Developing States, which was signed in 1994.Mr. Chowdhury said for Mauritius “we need a focused agenda.” He suggested the delegates identify priorities, to include the vulnerability – economic, social and environmental – of SIDS, poverty eradication measures, freshwater issues, climate change, renewable energy, development of marine resources and sustainable fisheries, HIV/AIDS, and trade.He said global advocacy for the cause of SIDS and the mobilization and coordination of international support for realizing the Mauritius outcome was vital in helping those countries face development challenges in the coming years.
123 Comments Jan 31st 2017, 8:34 PM Image: Shutterstock https://jrnl.ie/3215687 AUSTRIA’S CHANCELLOR HAS said he will seek to ban full-face veils in public, as part of a wide-ranging government programme aimed at fending off the challenge of the far-right.“The full-face veil will be banned in public spaces,” Christian Kern said after ministers signed off on the new programme of policies set to be implemented over the coming 18 months.There was no mention of a headscarf ban for civil servants but the text said that state representatives must “present themselves as religiously neutral”.Kern said he wanted to avoid “giving 600,000 Muslims in Austria the feeling that they are not part of our society.”The 35-page programme also includes beefing up surveillance and security measures, obliging migrants granted the right to stay to sign an “integration contract” and a “statement of values”.“Those who are not prepared to accept Enlightenment values will have to leave our country and society,” according to the text.It also promises the government will lower taxes and non-wage labour costs, restrict access of foreign workers to the Austrian labour market and create 70,000 new jobs.Many of the measures set out in the programme must be hammered out in detail and receive parliamentary approval before they can come into force.The move comes eight months after Kern, 51, replaced Werner Faymann at the head of an unhappy “grand coalition” between his Social Democrats (SPOe) and the centre-right People’s Party (OeVP).Both are facing a strong challenge from the Freedom Party (FPOe), which like similar groups across Europe has stoked concerns about immigration, security and the EU to top opinion polls.There has been speculation for months that the Austrian coalition might call early elections. The programme is aimed at showing it aims to govern until its mandate expires in late 2018.© – AFP 2017Read: Austrian police investigating reports of sexual assaults at New Year’s Eve celebration >Read: 89-year-old Holocaust survivor warns Austrians not to vote for far-right party > Image: Shutterstock By AFP Short URL Share Tweet Email1 Austria promises ban on face veil in public places The ban is part of raft of measures aimed at fending off the far-right. Tuesday 31 Jan 2017, 8:34 PM 16,202 Views Tweet thisShare on FacebookEmail this article
Twitter Google+ Kevin Nash Shares Heartfelt Condolences For WWEs Mean Gene Okerlund Now Playing Up Next Now Playing Up Next Videos Articles Ric Flair Braun Strowman Still Not Cleared For Match Now Playing Up Next The Rock Honors Mean Gene Okerlund Facebook Videos Articles Now Playing Up Next WhatsApp Adam Martin RELATED ARTICLESMORE FROM AUTHOR Ian Hunter Pinterest Ric Flair Pays Tribute To Late Friend Videos Articles WWE Female Superstars Get Green Light To Bounce Between Brands Gene Okerlund Now Playing Up Next Former UFC star and recently signed WWE talent Matt Riddle made his NXT TakeOver debut earlier tonight during the WarGames: II special in Los Angeles.Riddle, who was not advertised ahead of time for tonight’s NXT special on the WWE Network, specifically addressed comments by Kassius Ohno earlier in the night.Excerpt courtesy of Adam Martin’s live NXT TakeOver: WarGames II recap:Riddle said they are scheduled to wrestle next Wednesday on NXT, but he said we are chilling in L.A. and we have two rings down here and “I’ll knock you out in both of them, bro.”Here comes Kassius Ohno with a mic in hand. Ohno said Riddle is too stupid to know he shouldn’t be out here right now. He says Riddle is too stupid to know he’s not ready for TakeOver. Ohno suggests the referee rings the bell and hopes Riddle enjoys the moment, because he won’t be able to remember it after he knocks him out “bro.”Ohno slides in. Riddle with a high knee to Ohno, hooks the leg and gets the pinfall!Riddle picks up the victory in seconds. He jumps up on the top turnbuckle and starts celebrating immediately. Ohno is already struggling to try and get to his feet.Recommended videosPowered by AnyClipRic Flair Pays Tribute To Late FriendVideo Player is loading.Play VideoPauseUnmuteDuration 0:30/Current Time 0:03Loaded: 100.00%0:03Remaining Time -0:27 FullscreenUp NextThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Replay the list 9/13 NXT Live Results: Cocoa, FL (Dain vs. Kushida, NXT North American Title Match) WALTER and Kassius Ohno set to compete at EVOLVE 135 and 136 Live Events NXT Highlights: Johnny Gargano addresses NXT future, Baszler vs. Ripley, Pete Dunne in action
DHAKA, Bangladesh — The death toll from massive landslides triggered by heavy rains rose to 132 on Wednesday with firefighters, police and soldiers struggling to reach the remote southeastern districts to distribute aid, officials said.It was not clear yet if any villagers were still missing after large chunks of mud swept over thatched homes and settlements in three hilly districts on Tuesday, a day after heavy rains began across the country because of the influence of a depression in the Bay of Bengal.After an overnight halt in the search and rescue operation, rescuers resumed Wednesday morning, said Reaz Ahmed, a senior official of the Disaster Management Ministry.Military spokesman Rezaul Karim said Tuesday that several soldiers were killed and five injured while clearing debris and mud from a highway.Rains that began early Monday had cleared, allowing rescuers to work faster in searching for survivors. But some areas still remained cut off.Bangladesh is in the middle of the monsoon season, but Monday’s downpour was caused by a depression in the Bay of Bengal.Officials said at least 98 of the victims died in Rangamati, one of the worst-hit districts, and 28 were killed in Chittagong while another six died in Bandarban. Extensive devastation was reported in the region. The landslides were the worst since 2007, when 127 people were killed in Chittagong.In Rangamati’s remote Kawkhali area, about 5,000 homes were either destroyed or damaged, police chief Addul Karim said. He said authorities opened six temporary shelters.
November 6, 2018 Gasoline tax repeal proposal fails in California Posted: November 6, 2018 AP LOS ANGELES (AP) — A proposal to repeal a gasoline tax increase for transportation projects in California was trailing Tuesday in early returns.Proposition 6 had about 44 percent of the vote after polls closed Tuesday with nearly 2.9 million votes counted.The Republican-backed measure would repeal an increase in fuel taxes and vehicle fees that is expected to fund $5 billion a year in road fixes and transit improvements over a decade. It would also require voter approval for any future gasoline tax hikes.Republicans hoped the measure would boost GOP turnout in contested congressional and state races. They argue that California is too expensive and should spend its money more wisely to meet transportation needs.The Legislature, led by Democrats, passed the fuel tax increase last year to generate about $52 billion for transportation funding. Opponents of the repeal, including construction industry leaders and unions, contend the funds are critical to fix aging freeways and bridges and improve transit. AP, Gas Tax Repeal Goes Down. Leaders Of Prop 6 Say Corruption Killed It. Deceiving Ballot Language Never Mentioned “Tax Repeal”. Gas Taxes Remain Highest In America! pic.twitter.com/OpRWgXiSli— Dan Plante (@DanPlanteKUSI) November 7, 2018Much of the money is generated through a 12 cent-per-gallon boost in gasoline excise taxes that took effect last November.The repeal was proposed by San Diego talk radio host Carl DeMaio, who led a successful recall campaign earlier this year against a Democratic state lawmaker from Orange County who voted for the fuel tax increase.Republicans and Democrats agree that California needs a transportation overhaul as suburban commuters clamor for freeway fixes and city dwellers demand mass transit, but they differ on where the money should come from.Those who support the initiative argue that California ought to use existing funds for transportation improvements.Opponents contend there aren’t enough funds to keep up with the transportation needs of California’s 40 million people. Over the past two decades, cars have become more fuel efficient — a boon for the environment but a challenge to transportation budgets as drivers need less gasoline.Proponents argued during the campaign that the measure was assigned a misleading ballot title — “eliminates certain road repair” — that doesn’t immediately tell voters that it’s a repeal proposal. Categories: California News, Local San Diego News Tags: Decision 2018, Gas tax repeal FacebookTwitter
FORT LAUDERDALE, FLA. (WSVN) – The daughter of one of the stars of the “The Matrix” was arrested on DUI charges in South Florida over the weekend.Twenty-five-year-old Montana Fishburne, daughter of actor Lawrence Fishburne, was arrested by the Florida Highway Patrol after she crashed along Interstate 95, Saturday.She was charged with DUI with property damage and cuffed after the accident.Fishburne is currently out on bound.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
BRIDGEWATER, MA — More than 2,100 bachelor’s degrees in the sciences, arts, business and education were awarded during two ceremonies at Bridgewater State University on Saturday, May 12 on the Boyden Quadrangle. It was the 177th Spring Commencement Convocation in the university’s history.The following Wilmington residents were among those who graduated:Kimberly Ann DonoghueKathryn Carmen GoodwinJared H. LloydKatherine McKennaShannon Elizabeth MoultonMaria Elizabeth PatroneMichaela Catherine RodenhiserAmy ScottSophie Beth Serna(NOTE: The above modified press release is from Bridgewater State University.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Share this:TwitterFacebookLike this:Like Loading… RelatedSTUDENT SPOTLIGHT: 6 Wilmington Students Graduate From Bridgewater State UniversityIn “Education”STUDENT SPOTLIGHT: 6 Wilmington Students Named To Dean’s List At Bridgewater State UniversityIn “Education”STUDENT SPOTLIGHT: 6 Wilmington Students Named To Dean’s List At Bridgewater State UniversityIn “Education”
The death toll in the twin hooch tragedies in India’s Uttar Pradesh and neighbouring Uttarakhand has increased to 97, with over 200 people arrested in a police crackdown, officials said on Sunday.A total of 64 deaths were reported in Uttar Pradesh — 54 in Saharanpur district and 11 in Kushinagar.Saharanpur district magistrate Alok Kumar Pandey told IANS that of the 46 post-mortems conducted so far, 36 were confirmed to have died due to the consumption of spurious liquor.Meerut Superintendent of Police (SP) Ranvijay Singh said 14 people undergoing treatment at the Meerut Medical College, were in serious condition.Meanwhile, 32 deaths were also reported in Haridwar, Uttarakhand, according to Excise Department officialsThe Uttar Pradesh victims had visited Balupur in Roorkie, Uttarakhand, on 7 February for a funeral after which they consumed the illicit liquor, police sources said.In the police crackdown, 9,269 litres of hooch was seized in Uttar Pradesh while 1,066 litres was recovered in Uttarakhand.A total of 215 persons have been arrested in Uttar Pradesh, while cases against 297 persons have been filed. Forty-nine cases have been registered in Uttarakhand.The Uttar Pradesh government has ordered a magisterial enquiry into the tragedy and many officials of the police and the Excise Department have been suspended.
The application of semiconducting polymer nanoparticles (SPNs) to an activatable nanoprobe for imaging reactive oxygen species (ROS) in an edema mouse model. Credit: Jianghong Rao Rao describes some of the paper’s interesting and important findings, starting with their fundamental demonstration that near-infrared light-absorbing semiconducting polymer nanoparticles can serve as an efficient and stable nanoplatform to allow photons to be used to generate ultrasound waves, permitting in vivo photoacoustic molecular imaging. “Semiconducting polymer nanoparticles can absorb a large amount of near-infrared light,” he explains. “The absorbed energy is then dissipated as heat to generate sound waves and these waves can be detected by the ultrasound transducer and in turn exploited for photoacoustic imaging. Addressing another result – that activatable molecular imaging probes can undergo an intrinsic signal evolution upon detecting molecular targets or events, providing a real-time correlation between probe activated versus non-activated states and pathological processes on a molecular level – Rao points out that in this study, the probe produces photoacoustic signals at two different wavelengths (700 nm and 820 nm) before activation by the ROS (reactive oxygen species) molecular target. “After activation,” he adds, “the signal at 820 nm is lost, and the signal at 700 nm remains. Thus this signal change reflects the presence and activity of the target. The imaging acquisition is fast, so the detection can be in real time. The imaging captures molecular change of the probe that reflects the activity of the ROS molecular target in the disease.”The paper emphasizes that full utilization of the potential of photoacoustic imaging at a depth and spatial resolution that is unattainable by fluorescence imaging requires new materials amenable to the construction of activatable photoacoustic probes. “Activatable probes can allow one to detect physiological and pathological molecular events,” Rao explains. “However, most current activatable probes rely on fluorescence, which doesn’t provide the deep imaging depth and high spatial resolution that photoacoustic imaging does.”Moving forward, Rao says, the scientists are continuing to explore their application for imaging – for example, photoacoustic imaging of cancer by attaching a tumor-targeting molecule to the nanoparticle. “Another area will be to explore more polymers that absorb at different near-infrared wavelength,” he adds, “allowing multiple target imaging to be done simultaneously. Moreover, while this work demonstrates the imaging of reactive oxygen species, other molecular targets, such as pH and enzyme species, may be similarly imaged.” Rao also points out that it may be possible for the new approach to be combined with drug delivery, effectively creating so-called theranostic nanoparticles for personalized healthcare applications by testing patients for possible reactions to a new medication, and then tailoring a treatment for them based on the test results.Rao lists a number of applications that will emerge as a result of their research. “Our research will most likely lead to the use of semiconducting nanoparticles for photoacoustic imaging on pre-clinical animal models, such as imaging ROS in deep tissue locations in diseases,” he says. “It could also lead to the development of other semiconducting polymer-based photoacoustic imaging probes, both targeting probes by conjugating a targeting ligand” (a small molecule that forms a complex with a biomolecule to serve a biological purpose) “and activatable probes signal activation by molecular targets other than ROS.”Regarding other areas of research that might benefit from their study, Rao tells Phys.org that the new nanomaterial should enhance the ability to study cancer, neurodegenerative, cardiovascular, and many other diseases in animal models, and help uncover the role of aberrant RONS (reactive oxygen and nitrogen species) in these diseases and contribute to the development of novel therapeutics. “With the translation of photoacoustic imaging to clinics,” Rao concludes, “it may be applied to clinical research as well.” More information: Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice, Nature Nanotechnology 9(3), 233–239 (2014), DOI: 10.1038/nnano.2013.302 Explore further Unwanted side effect becomes advantage in photoacoustic imaging Prof. Jianghong Rao discussed the paper that he, Dr. Kanyi Pu and their co-authors published in Nature Nanotechnology. “Firstly, there are several ideal properties a photoacoustic imaging probe should have,” Rao tells Phys.org. “These are no or low toxicity, high photoacoustic efficiency, excellent photostability and chemical stability, absorption in infrared or near-infrared wavelength to avoid the tissue background light absorption and achieve better light penetration, and –for a molecular imaging probe – the ability to generate target-specific photoacoustic imaging contrast.” However, Rao continues, current photoacoustic contrast agents generally do not meet all of these requirements, having either have poor photostability, poor oxidation stability, or toxicity concerns. While photoacoustic imaging promises to significantly advance molecular-level physiological and pathological visualization with deep tissue penetration and fine spatial resolution, photoacoustic molecular imaging probes must first be developed.On the other hand, Rao notes that semiconducting polymer nanoparticles offer a number of attractive features, including being a photoacoustic imaging contrast agent, no use of toxic metals, being biologically inert, having high photostability, are resistant against oxidation, and the ability to be made with high near-infrared light absorption. “The main question,” he explains, “was whether it was efficient for semiconducting polymer nanoparticles to produce acoustic signals after light excitation – and we had to examine the type of polymer to determine this. All this said, the big challenge for molecular photoacoustic imaging probes is whether they can produce a specific signal in response to their molecular targets. This requires a signal activation mechanism controlled by the molecular target.”In addressing these challenges, Rao says that their key insight was that a semiconducting polymer can be formulated into a water-soluble nanoparticle and, depending on its structure, the resultant nanoparticles can be highly efficient for photoacoustic imaging. “Our key innovation in designing semiconducting polymer nanoparticles into a phootoacoustic molecular imaging probe was to introduce ratiometric imaging widely used in fluorescence imaging,” he says. Ratiometric imaging techniques observe emission wavelength shifts of fluorophores (fluorescent chemical compounds that can re-emit photons upon light excitation) or by comparing the emission intensity of a fluorophore combination instead of measuring mere intensity changes. “By exciting the probe at two different wavelengths, the target activation leads to the change in the photoacoustic signal at one wavelength, so the ratio of the signals at two wavelengths will change accordingly. This allowed us to create a target-specific photoacoustic signal.” This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Journal information: Nature Nanotechnology © 2014 Phys.org. All rights reserved. Citation: Of mice and molecules: In vivo photoacoustic imaging using semiconducting polymer nanoparticles (2014, March 27) retrieved 18 August 2019 from https://phys.org/news/2014-03-mice-molecules-vivo-photoacoustic-imaging.html (Phys.org) —Photoacoustic imaging is a hybrid biomedical imaging modality, based on the photoacoustic effect, in which non-ionizing laser pulses are delivered into biological tissues. (More specifically, in the photoacoustic effect sound waves form due to pressure changes when a material absorbs varying-intensity modulated or pulsed light. These waves are then detected by, for example, microphones or piezoelectric sensors. The resulting photoacoustic signal is the current or voltage that provides the value indicating how the sound waves vary in time.) Recently, scientists at Stanford University developed a new class of contrast agents for photoacoustic molecular imaging – namely, near-infrared (NIR) light absorbing semiconducting polymer nanoparticles (SPNs) that produce a stronger signal than single-walled carbon nanotubes and gold nanorods – properties that allowed the researchers to perform whole-body lymph-node photoacoustic mapping on living laboratory mice. In addition, these semiconducting polymer nanoparticles possess high structural flexibility, narrow photoacoustic spectral profiles and strong resistance to photodegradation and oxidation – qualities essential to the designing the first near-infrared ratiometric photoacoustic probe for in vivo real-time imaging of the reactive oxygen species (ROS) that mediate many diseases. In short, the researchers say, their results show semiconducting polymer nanoparticles to be the perfect nanoplatform for the development of photoacoustic molecular probes.
Gen (Dr) VK Singh, Minister of State for External Affairs and MOS (IC) Statistics and Programme Implementation, released the book authored by Dr D Bhalla, IAS, Secretary Lok Sabha Secretariat recently in the national Capital.The author has brought out the long history of political unrest, neglect, under-development and insurgency in the Northeastern region — all issues impacting the security of the country and the economic well-being of the Northeast. Also Read – ‘Playing Jojo was emotionally exhausting’One aspect that makes the region strategic from the security point of view, is that most of the states have international borders with other countries. Besides the geography, people and commercial potential of the region, Dr Bhalla has dwelt at length about insurgency, various facets of strategic importance and suggested future policies to bring out the full potential of the region.Gen Dr VK Singh said, “There was no doubt that India’s foreign policy and relations with neighbouring countries will have a profound effect on the future of the Northeast, primarily because the neighbouring countries have common borders and affinities with one or more states.” The book is a fresh attempt, with a practical approach towards Northeast.
Register Now » This story originally appeared on PCMag Growing a business sometimes requires thinking outside the box. Facebook-owned Oculus is curtailing an experiment that let Best Buy shoppers try out the Oculus Rift virtual reality headset before buying one, the company told Business Insider this week.The demonstrations began last May and were available in as many as 500 Best Buy stores nationwide. That number will now be scaled back to around 300, according to an Oculus spokesperson, who attributed the reduction to a change in seasonal demand.”We’re making some seasonal changes and prioritizing demos at hundreds of Best Buy locations in larger markets,” the spokesperson told Business Insider.If you’re hoping to test drive a Rift before you buy one, you can check the Oculus website for a list of Best Buy stores that are still participating. The site allows you to schedule an appointment for your demo, which includes VR vignettes with Oculus Dreamdeck, rock climbing in The Climb and a brief tour through the alien worlds of Farlands.For those who can’t get to a participating Best Buy, Oculus still plans to do “regular events and pop ups in retail locations and local communities throughout the year,” according to the spokesperson.The move to scale back retail demonstrations comes one week after Oculus was ordered to pay $500 million in damages to video game publisher ZeniMax Media, which sued it for misappropriating technology that was later used in the Rift. ZeniMax initially leveled multiple charges against Oculus, including putting its trade secrets and copyrighted computer code at risk, but the jury cleared Oculus of most of them.Facebook CEO Mark Zuckerberg, who testified in the ZeniMax trial, is still bullish about Oculus and VR in general. At the Oculus developers’ conference last year, he said he believes that in 20 years, VR will become the main form of computing. Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global 2 min read February 9, 2017
RelatedFlights to Melbourne from Doha readied for December launchQatar Airways has announced its intention to commence flights to Australia before the end of the year.Flights to Melbourne from Doha readied for December launchQatar Airways has announced its intention to commence flights to Australia before the end of the year.Flights to Melbourne from Doha readied for December launchQatar Airways has announced its intention to commence flights to Australia before the end of the year. Qatar Airways has announced its intention to launch new flights to Australia and increase its flight network in India and Europe.The plans, which form part of the airline’s northern winter 2009 schedules, involve the introduction of flights to Sydney and Melbourne and services to Goa and Amritsar in India.Furthermore, Qatar Airways will be looking to launch two new European flights during the next nine months.Akbar Al Baker, the airline’s chief executive, said that the current economic downturn would not affect the carrier’s expansion plans.”We can finally look forward to entering the Australian market with vigour as we will have the aircraft to serve this highly popular market non-stop from Doha,” he said.Mr Al Baker added that he was “pleased” to be expanding into India, saying that establishing air links between Qatar and one of the world’s fastest growing economies is “of paramount importance”.Qatar Airways announced last month that it would reduce its fuel surcharges on flights in its international network.ReturnOne wayMulti-cityFromAdd nearby airports ToAdd nearby airportsDepart14/08/2019Return21/08/2019Cabin Class & Travellers1 adult, EconomyDirect flights onlySearch flights Map
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